We have open positions for highly motivated students with background in molecular biology who are looking for Master thesis projects. The projects are usually running for about six month full time. The main focus for the projects will be using mass spectrometry based proteomics methods and approaches to adress questions in current cancer research.
Currently available master thesis projects:
Using Thermal Proteome Profiling for evaluating therapeutics in Childhood Acute Lymphoblastic Leukemia
The student will be engaged in using a pioneering approach for drug target engagement combined with mass spectrometry for measuring direct biophysical interactions of therapeutics in Acute Lymphoblastic Leukemia cell lines. Initially the project will involve screening of different known small molecule drugs in various ALL cell lines with different genetic background and assessing their potency and effect on viability using cellular thermal shift assay as well as viability assays. In the latter part of the project thermal proteome profiling will be used to investigate selected small molecule drugs in a suitable cell line for target and off-target identifications.
For more information regarding this project contact Rozbeh Jafari email@example.com
Developing click-based work flow for isolation of small molecule binding proteins in Neuroblastoma
The student will be using bio-orthogonal ligation strategies to identify small molecule binding proteins from cell line models.
For more information regarding this project contact Jürgen Eirich firstname.lastname@example.org
Developing a tool for accurate peptide isoelectric (pI) point prediction.
The student will use machine learning algorithms to develop a tool for peptide isoelectric point prediction. Currently, we have collected experimental pI values for several hundred thousands of peptides, which can be used as training set. A more challenging task is to advance the tool to predict pI of peptides with post translational modifications.
For more information regarding this project contact Yafeng Zhu email@example.com