Rozbeh Jafari is an assistant professor at the Department of Oncology-Pathology. His research focuses on combining the cellular thermal shift assay with mass spectrometry for proteome wide drug target engagement in childhood leukemia’s for identifying novel predictive biomarkers for drug efficacy and resistant development.
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
The cellular thermal shift assay for evaluating drug target interactions in cells
Tracking cancer drugs in living cells by thermal profiling of the proteome
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay